Cloma Pharma, a dietary supplement manufacturer in the United States, is one of the oldest manufacturers of nutritional supplements containing ephedra. Cloma Pharma is one of the pioneer manufacturers that first used ephedra in their supplements to aid in weight loss, appetite suppressing, and energy-boosting. They currently have five weight loss supplements, all containing 25mg of Ephedra. Black Spider with 25mg of ephedra is their best selling ephedra diet pill. Methlydrene 25 Original and Methyldrene 25 Elite are two of their most popular products.